Pyrazole-5-carboxylic acid, 3-phenyl- → (3-Phenyl-1H-pyrazol-5-yl)(3,4,5-trimethoxyphenyl)methanone
Reaktionsgleichung
C1(C2N=C([C:13]([C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)=[O:14])C=CC=2)C=CC=CC=1.[C:27]1([C:33]2[CH:37]=[C:36](C(O)=O)[NH:35][N:34]=2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:27]1([C:33]2[CH:37]=[C:36]([C:13]([C:15]3[CH:16]=[C:17]([O:25][CH3:26])[C:18]([O:23][CH3:24])=[C:19]([O:21][CH3:22])[CH:20]=3)=[O:14])[NH:35][N:34]=2)[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1Komponenten
3
Versuchsvorschrift
(3-Phenyl-1H-pyrazol-5-yl)(3,4,5-trimethoxyphenyl)methanone (1k) was prepared using the same method as used of compound 1c from 3-phenyl-1H-pyrazole-5-carboxylic acid. 1H NMR (500 MHz, CDCl3 δ 10.97 (br, 1H), 7.77 (s, br, 2H), 7.48-7.38 (m, 5H), 7.14 (s, br, 1H), 3.96 (s, 3H), 3.94 (s, 6H); MS (ESI) m/z 361.1 (M+Na)+, 337.0 (M−H)−.
Quellen und Nachweise
- ORD-Eintrag
- ord-0bf7f0028cc841cc8f8dfe7667fb1429
- Quelldatensatz
- uspto-grants-2016_09