Sodium Cyanide → 5-Methylpicolinonitrile

HRID 632045

Reaktionsgleichung

Reaktionsgleichung von HRID 632045
F[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.[C-:9]#[N:10].[Na+]>CS(C)=O>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([C:9]#[N:10])=[N:3][CH:4]=1

Komponenten

4

Edukt 2

HCID 8929Sodium CyanideHCID 27746352-Fluoro-5-methylpyridine

Produkt 1

HCID 741835-MethylpicolinonitrileAusbeute 249,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

2-Fluoro-5-methylpyridine (CAN 2369-19-9, 50 g, 90 mmol) and sodium cyanide (CAN 143-33-9, 70 g, 1.43 mol) were dissolved in DMSO (200 mL), the mixture was stirred for 3 days at 150° C. The mixture was cooled to room temperature, ice water (200 mL) was added and the product was obtained as red solid (26.5 g, 50%) by filtration and drying; MS (EI): m/e 119.1 [M+H]+.

Aufarbeitung

  1. temperatureThe mixture was cooled to room temperature

Quellen und Nachweise

ORD-Eintrag
ord-a2d02657fadf4d4cb7decf83e003a87a
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

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