5-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → 5-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid [(S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

HRID 632052Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 632052
[CH:1]1([C:6]2[CH:7]=[CH:8][C:9]([C:17]([OH:19])=O)=[N:10][C:11]=2[O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:20]1([CH2:23][C@H:24]([NH2:31])[C:25]2[N:29]=[C:28]([CH3:30])[O:27][N:26]=2)[CH2:22][CH2:21]1>>[CH:20]1([CH2:23][C@H:24]([NH:31][C:17]([C:9]2[CH:8]=[CH:7][C:6]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)=[C:11]([O:12][CH2:13][CH:14]3[CH2:15][CH2:16]3)[N:10]=2)=[O:19])[C:25]2[N:29]=[C:28]([CH3:30])[O:27][N:26]=2)[CH2:22][CH2:21]1

Komponenten

3

Edukt 2

HCID 710875595-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 86674748(S)-2-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine

Produkt 1

HCID 711055665-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid [(S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 5-cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 39 b) and (S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (Example 38 e) as starting materials, MS (LC/MS): 411.2 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-3157dfa83d7b485683741398acbfcd1a
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

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