(S)-alpha-amino-cyclopropanepropanamide → 5-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-carbamoyl-2-cyclopropyl-ethyl)-amide

HRID 632134

Reaktionsgleichung

Reaktionsgleichung von HRID 632134
[CH:1]1([C:6]2[CH:7]=[CH:8][C:9]([C:17]([OH:19])=O)=[N:10][C:11]=2[O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:20][C@@H:21]([CH2:25][CH:26]1[CH2:28][CH2:27]1)[C:22]([NH2:24])=[O:23]>>[C:22]([C@@H:21]([NH:20][C:17]([C:9]1[CH:8]=[CH:7][C:6]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[C:11]([O:12][CH2:13][CH:14]2[CH2:15][CH2:16]2)[N:10]=1)=[O:19])[CH2:25][CH:26]1[CH2:28][CH2:27]1)(=[O:23])[NH2:24]

Komponenten

3

Edukt 2

HCID 53964035(S)-alpha-amino-cyclopropanepropanamideHCID 710875595-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Produkt 1

HCID 711055965-Cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-1-carbamoyl-2-cyclopropyl-ethyl)-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 5-cyclopentyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 39 b) and (S)-2-amino-3-cyclopropyl-propionamide (CAN 156077-93-9) as starting materials, MS (EI): m/e=372.3 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-a60729cc9f964c64b1a4e5fe35aff68c
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

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