5-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid → 2-{[5-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid methyl ester

HRID 632288Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 632288
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)[CH2:3][CH2:2]1.Cl.[NH2:21][C:22]([CH2:29][CH3:30])([CH2:27][CH3:28])[C:23]([O:25][CH3:26])=[O:24]>>[CH3:26][O:25][C:23](=[O:24])[C:22]([NH:21][C:17]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)[N:8]=1)=[O:19])([CH2:29][CH3:30])[CH2:27][CH3:28]

Komponenten

3

Edukt 2

HCID 710872545-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acidHCID 75488114Methyl 2-amino-2-ethylbutanoate hydrochloride

Produkt 1

HCID 710876662-{[5-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid methyl ester

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 166 b) and methyl 2-amino-2-ethylbutanoate hydrochloride (CAN 92398-54-4) as starting materials, MS (EI): m/e=391.3 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-8c18970e795044f7b42a1c6518153688
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

Notizen zur Reaktion

Wird geladen…