3,3-Difluoroazetidine hydrochloride → 2-{[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3,3-Difluoroazetidine hydrochloride	HCID 2758247	—
Edukt	2-[(5-Bromo-6-cyclopropylmethoxy-pyridine-2-carbonyl)-amino]-2-ethyl-butyric acid ethyl ester	HCID 71087280	—
Produkt	2-{[6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carbonyl]-amino}-2-ethyl-butyric acid ethyl ester	HCID 71087467	—

Reaktionsschritte

The title compound was synthesized in analogy to the procedure described in Example 69 a, using ethyl 2-(5-bromo-6-(cyclopropylmethoxy)picolinamido)-2-ethylbutanoate (Example 265) and 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) as starting materials. MS (EI): m/e=426.0 [M+H]+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09321727B2
Quelldatensatz	uspto-grants-2016_04
ORD ID	ord-238edc61f7604f7dadf12658da230bee
Quellennotiz	uspto-grants-2016_04