5-Methyl-alpha-(2-methylpropyl)-1,2,4-oxadiazole-3-methanamine → 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [3-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-butyl]-amide

HRID 632326Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 632326
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[CH3:21][C:22]1[O:26][N:25]=[C:24]([CH:27]([CH2:29][CH:30]([CH3:32])[CH3:31])[NH2:28])[N:23]=1>>[CH3:31][CH:30]([CH3:32])[CH2:29][CH:27]([NH:28][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[C:24]1[N:23]=[C:22]([CH3:21])[O:26][N:25]=1

Komponenten

3

Edukt 2

HCID 435593295-Methyl-alpha-(2-methylpropyl)-1,2,4-oxadiazole-3-methanamineHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Produkt 1

HCID 711145386-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid [3-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-butyl]-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and 5-methyl-α-(2-methylpropyl)-1,2,4-oxadiazole-3-methanamine (CAN 1155538-06-9) as starting materials. MS (EI): m/e=436.0 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-93e4c969b6414dbca0f3790c1525c833
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

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