(2S)-2-amino-N,4,4-trimethyl-pentanamide → 5-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

HRID 632440

Reaktionsgleichung

Reaktionsgleichung von HRID 632440
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[S:10]([CH2:13][CH:14]([CH3:16])[CH3:15])(=[O:12])=[O:11])[CH2:3][CH2:2]1.[NH2:20][C@@H:21]([CH2:26][C:27]([CH3:30])([CH3:29])[CH3:28])[C:22]([NH:24][CH3:25])=[O:23]>>[CH3:28][C:27]([CH3:30])([CH3:29])[CH2:26][C@H:21]([NH:20][C:17]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([S:10]([CH2:13][CH:14]([CH3:15])[CH3:16])(=[O:11])=[O:12])[N:8]=1)=[O:19])[C:22](=[O:23])[NH:24][CH3:25]

Komponenten

3

Edukt 2

HCID 57635521(2S)-2-amino-N,4,4-trimethyl-pentanamideHCID 710877315-Cyclopropyl-6-(isobutylsulfonyl)picolinic acid

Produkt 1

HCID 711057495-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(isobutylsulfonyl)picolinic acid (Example 351 b) and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials. MS (EI): m/e=424.6 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-0400da0c6d9b45879690ee3c2620a23c
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

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