Leucinamide → 5-Cyclopropyl-6-(2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

HRID 632453

Reaktionsgleichung

Reaktionsgleichung von HRID 632453
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[O:10][CH:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])[CH2:3][CH2:2]1.[NH2:20][C@@H:21]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:22]([NH2:24])=[O:23]>>[C:22]([C@@H:21]([NH:20][C:17]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH:11]([CH3:16])[C:12]([F:13])([F:14])[F:15])[N:8]=1)=[O:19])[CH2:25][CH:26]([CH3:28])[CH3:27])(=[O:23])[NH2:24]

Komponenten

3

Edukt 2

HCID 69640LeucinamideHCID 710874355-Cyclopropyl-6-(1,1,1-trifluoropropan-2-yloxy)picolinic acid

Produkt 1

HCID 866748025-Cyclopropyl-6-(2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(1,1,1-trifluoropropan-2-yloxy)picolinic acid and (2S)-2-amino-4-methyl-pentanamide (CAN 687-51-4) as starting materials. MS (EI): m/e=388.4 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-4aafd77e2b114873849b03f0771e2009
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321727B2

Verknüpfte Notizen

Wird geladen…