[2-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]phenyl]methanol → 2-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]benzaldehyde

HRID 632507

Reaktionsgleichung

Reaktionsgleichung von HRID 632507
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)[CH:6]=[CH:5][C:4]=1[CH2:17][OH:18]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)[CH:6]=[CH:5][C:4]=1[CH:17]=[O:18]

Komponenten

4

Edukt 1

HCID 117888927[2-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]phenyl]methanol

Produkt 1

HCID 897259352-Methoxy-4-[(4-methylpiperazin-1-yl)methyl]benzaldehydeAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

To 220 mL of a solution of 22.2 g of [2-methoxy-4-[(4-methylpiperazin-1-yl)methyl]phenyl]methanol in CHCl3 was added 61.8 g of manganese dioxide, and the mixture was stirred at 55° C. for 13 hours. The reaction mixture was allowed to stand to cool. After insoluble matter was filtered off, the mother liquor was concentrated to give 21.8 g of the title compound (99% yield).

Aufarbeitung

  1. temperatureto cool
  2. filtrationAfter insoluble matter was filtered off
  3. concentrationthe mother liquor was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-976cd24524544abd984e681c5980a3aa
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321752B2

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