Ammonia → HCID 58497086, Verbindung

HRID 632715Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 632715
[Cl:1][C:2]1[C:7]([CH2:8][CH3:9])=[C:6](Cl)[N:5]=[CH:4][N:3]=1.O=P(Cl)(Cl)Cl.[NH3:16]>C1(C)C=CC=CC=1.C(O)CCC>[NH2:16][C:6]1[C:7]([CH2:8][CH3:9])=[C:2]([Cl:1])[N:3]=[CH:4][N:5]=1

Komponenten

6

Edukt 3

HCID 222AmmoniaHCID 24813Phosphorus oxychlorideHCID 218284324,6-Dichloro-5-ethylpyrimidine2×

Produkt 1

HCID 58497086HCID 58497086, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 2631-ButanolLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

Formamidine acetate was reacted with diethyl-ethylmalonate in the presence of sodium ethoxide in dry ethanol to yield 5-ethylpyrimidine-4,6-diol, which was converted to 4,6-Dichloro-5-ethylpyrimidine by POCl3 in the presence of TEA in toluene. 4,6-Dichloro-5-ethylpyrimidine was then reacted with aqueous ammonia in n-butanol at 100° C. to afford 4-amino-5-ethyl-6-chloropyrimidine.

Quellen und Nachweise

ORD-Eintrag
ord-fefd416154464c70b09f21a099e8ecd4
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321760B2

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