5-(Benzyloxy)-2-tert-butylpyridine → 6-Tert-butylpyridin-3-ol

HRID 63278Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 63278
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11]CC2C=CC=CC=2)=[CH:7][N:6]=1)([CH3:4])[CH3:3]>C(O)C.[OH-].[OH-].[Pd+2]>[CH3:4][C:2]([C:5]1[N:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1)([CH3:1])[CH3:3]

Komponenten

4

Edukt 1

HCID 207095055-(Benzyloxy)-2-tert-butylpyridine

Produkt 1

HCID 229582676-Tert-butylpyridin-3-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 2-(1,1-dimethylethyl)-5-[(phenylmethyl)oxy]pyridine, (5.3 g) in ethanol (150 ml) was added 20% Pd(OH)2 (12.3 g) at 25-30 C. The above mixture was purged with hydrogen for 3 h until it had gone to completion by tlc. The reaction mixture was filtered through celite and the filtrate concentrated in vacuo and purified to give the title compound, 3.9 g

Aufarbeitung

  1. customThe above mixture was purged with hydrogen for 3 h until it
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationthe filtrate concentrated in vacuo
  4. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-25c309b0913641e2a7acc15eab8c2660
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447074B2

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