Phosphorus oxychloride → 4-Chloro-6-ethyl-5-iodopyrimidine

HRID 632877

Reaktionsgleichung

Reaktionsgleichung von HRID 632877
O[C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:13]>>[Cl:13][C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 1784377446-ethyl-5-iodo-1H-pyrimidin-4-one

Produkt 1

HCID 109784874-Chloro-6-ethyl-5-iodopyrimidine

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additionthe residue is poured
  3. custominto crushed ice
  4. filtrationThe precipitated solid is collected by filtration
  5. washwashed with water
  6. customAfter drying

Quellen und Nachweise

ORD-Eintrag
ord-183e56c017914ce48ce8cdeb73f423ed
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321771B2

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