Acetonitrile → 3-(4-Bromothiophen-2-yl)-3-hydroxypropanenitrile

HRID 63303

Reaktionsgleichung

Reaktionsgleichung von HRID 63303
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[O:8])[S:5][CH:6]=1.[CH3:9][C:10]#[N:11]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]([OH:8])[CH2:9][C:10]#[N:11])[S:5][CH:6]=1

Komponenten

3

Edukt 2

HCID 6342AcetonitrileHCID 877924-Bromothiophene-2-carbaldehyde

Produkt 1

HCID 866945903-(4-Bromothiophen-2-yl)-3-hydroxypropanenitrile

Versuchsvorschrift

Addition of CH3CN to 4-bromothiophene-2-carbaldehyde following the method used in Example 2 gave 3-(4-bromothiophen-2-yl)-3-hydroxypropanenitrile as a light brown oil which was used in the next step without additional purification. Yield (1.95 g, 80%).

Quellen und Nachweise

ORD-Eintrag
ord-0b4c34a7edb944d7980955e9f1862dbf
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447078B2

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