2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-amine → 2-[({2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl}carbamoyl)amino]-1,3-benzothiazol-6-yl thiocyanate

HRID 633485

Reaktionsgleichung

Reaktionsgleichung von HRID 633485
[S:1]([C:4]1[CH:22]=[CH:21][C:7]2[N:8]=[C:9]([NH:11][C:12](=[O:20])OC3C=CC=CC=3)[S:10][C:6]=2[CH:5]=1)[C:2]#[N:3].[CH3:23][C@H:24]1[O:29][C@@H:28]([CH3:30])[CH2:27][N:26]([CH2:31][CH2:32][NH2:33])[CH2:25]1>>[CH3:30][C@H:28]1[O:29][C@@H:24]([CH3:23])[CH2:25][N:26]([CH2:31][CH2:32][NH:33][C:12]([NH:11][C:9]2[S:10][C:6]3[CH:5]=[C:4]([S:1][C:2]#[N:3])[CH:22]=[CH:21][C:7]=3[N:8]=2)=[O:20])[CH2:27]1

Komponenten

3

Edukt 2

HCID 71449682-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-amineHCID 53472570Phenyl(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate

Produkt 1

HCID 866478792-[({2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl}carbamoyl)amino]-1,3-benzothiazol-6-yl thiocyanate

Versuchsvorschrift

The 2-[({2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl}carbamoyl)amino]-1,3-benzothiazol-6-yl thiocyanate was prepared according to the method described in Example 9c, but using 654 mg of phenyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate and 0.35 cm3 of 2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethanamine. 783 mg of 2-[({2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl}carbamoyl)amino]-1,3-benzothiazol-6-yl thiocyanate are thus obtained in the form of a white solid, the characteristics of which are as follows:

Aufarbeitung

  1. customThe 2-[({2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethyl}carbamoyl)amino]-1,3-benzothiazol-6-yl thiocyanate was prepared

Quellen und Nachweise

ORD-Eintrag
ord-8b8e1862e245442fb1dea22a3251896e
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321777B2

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