2-Morpholinoethylamine → 2-Morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate

HRID 633487

Reaktionsgleichung

Reaktionsgleichung von HRID 633487
[S:1]([C:4]1[CH:22]=[CH:21][C:7]2[N:8]=[C:9]([NH:11][C:12](=[O:20])[O:13][C:14]3[CH:19]=CC=CC=3)[S:10][C:6]=2[CH:5]=1)[C:2]#[N:3].[N:23]1(CCN)[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[S:1]([C:4]1[CH:22]=[CH:21][C:7]2[N:8]=[C:9]([NH:11][C:12](=[O:20])[O:13][CH2:14][CH2:19][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[S:10][C:6]=2[CH:5]=1)[C:2]#[N:3]

Komponenten

3

Edukt 2

HCID 4082852-MorpholinoethylamineHCID 53472570Phenyl(6-thiocyanato-1,3-benzothiazol-2-yl)carbamate

Produkt 1

HCID 867070062-Morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate

Versuchsvorschrift

The 2-morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate was prepared according to the method described in Example 9c, but using 654 mg of phenyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate and 0.27 cm3 of 2-morpholin-4-ylethanamine. The residue obtained is chromatographed on an Analogix cartridge of 40 g of silica 15-40 μm, elution being carried out with a gradient of dichloromethane then 95/5 dichloromethane/methanol. 729 mg of 2-morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate are thus obtained in the form of a white solid, the characteristics of which are as follows:

Aufarbeitung

  1. customThe 2-morpholin-4-ylethyl (6-thiocyanato-1,3-benzothiazol-2-yl)carbamate was prepared
  2. customThe residue obtained
  3. customis chromatographed on an Analogix cartridge of 40 g of silica 15-40 μm, elution

Quellen und Nachweise

ORD-Eintrag
ord-88ba77e7c48542979ff10be620b962a1
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321777B2

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