3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(6-methoxy-3,4-dihydro-2H-1-thia-9-aza-phenanthren-3-ylmethyl)-azetidin-3-yl]-amide

HRID 633831Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 633831
Br[CH2:2][CH:3]1[CH2:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=3)[N:8]=[CH:7][C:6]=2[S:5][CH2:4]1.C(OC([N:26]1[CH2:29][CH:28]([NH2:30])[CH2:27]1)=O)(C)(C)C.[O:31]=[C:32]1[NH:37][C:36]2[CH:38]=[C:39]([C:42](O)=[O:43])[CH:40]=[CH:41][C:35]=2[S:34][CH2:33]1>>[CH3:18][O:17][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]1[S:5][CH2:4][CH:3]([CH2:2][N:26]3[CH2:27][CH:28]([NH:30][C:42]([C:39]4[CH:40]=[CH:41][C:35]5[S:34][CH2:33][C:32](=[O:31])[NH:37][C:36]=5[CH:38]=4)=[O:43])[CH2:29]3)[CH2:16][C:15]2=1

Komponenten

4

Edukt 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 1516507Tert-butyl 3-aminoazetidine-1-carboxylateHCID 867307113-bromomethyl-6-methoxy-3,4-dihydro-2H-1-thia-9-aza-phenanthrene

Produkt 1

HCID 714755263-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(6-methoxy-3,4-dihydro-2H-1-thia-9-aza-phenanthren-3-ylmethyl)-azetidin-3-yl]-amide

Versuchsvorschrift

The titled compound is prepared as an off-white lyophilized powder following Scheme 1 and in analogy to Example 1 using 3-bromomethyl-6-methoxy-3,4-dihydro-2H-1-thia-9-aza-phenanthrene, 3-amino-azetidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

Quellen und Nachweise

ORD-Eintrag
ord-e3c7e9dbf6084b02aa7ff32ece7d4df7
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321788B2

Notizen zur Reaktion

Wird geladen…