Hydrochloric Acid → 3-(Pyrrolidin-3-yloxy)pyridine hydrochloride

HRID 633896Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 633896
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][CH:8]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)[CH:2]=1.[ClH:20]>ClCCl.O1CCOCC1>[ClH:20].[NH:10]1[CH2:11][CH2:12][CH:8]([O:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:9]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 10801570tert-Butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate

Produkt 1

HCID 534092893-(Pyrrolidin-3-yloxy)pyridine hydrochlorideAusbeute 58 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a cooled solution of tert-butyl 3-(pyridin-3-yloxy)pyrrolidine-1-carboxylate (600 mg, 2.27 mmol; which may be prepared as described in Step 1) in dichloromethane (15 mL) was added dropwise HCl 4N in dioxane (11.1 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (263 mg, 58%) as a yellow wax.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d17e2412df954aba8005f0b45f0c759e
Quelldatensatz
uspto-grants-2016_04
Patentnummer
US09321769B2

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