Hydrochloric Acid → 3-(Morpholin-4-yl)propanoic acid

HRID 634733

Reaktionsgleichung

Reaktionsgleichung von HRID 634733
[OH-].[K+].[O:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]([O:13]C)=[O:12])[CH2:5][CH2:4]1.Cl>C(O)C>[O:3]1[CH2:4][CH2:5][N:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:7][CH2:8]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 1013734-Morpholinepropanoic acid, methyl ester

Produkt 1

HCID 4108133-(Morpholin-4-yl)propanoic acidAusbeute 109,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Potassium hydroxide (485 mg, 8.6mmol) was added to a solution of methyl 3-morpholinopropionate (1 g, 5.7 mmol) in ethanol (20 ml) and the mixture stirred for 2 hours at 80° C. The solution was allowed to cool and adjusted to pH1 with 6M hydrochloric acid. Insoluble material was removed by filtration and the volatiles removed from the filtrate by evaporation. The resulting oil was triturated with ether, the solid product collected by filtration, washed with methylene chloride and dried under vacuum to give 3-morpholinopropionic acid (993 mg, 89%) as a white solid.

Aufarbeitung

  1. temperatureto cool
  2. customInsoluble material was removed by filtration
  3. customthe volatiles removed from the filtrate by evaporation
  4. customThe resulting oil was triturated with ether
  5. filtrationthe solid product collected by filtration
  6. washwashed with methylene chloride
  7. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-86cdfda27d254be487ffcb57eed83c91
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06184225B2

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