Dicyclohexylcarbodiimide → 4-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-(3-morpholinopropionamido)quinazoline

HRID 634734

Reaktionsgleichung

Reaktionsgleichung von HRID 634734
C1(N=C=NC2CCCCC2)CCCCC1.[O:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]([OH:26])=O)[CH2:18][CH2:17]1.Cl.[NH2:28][C:29]1[CH:38]=[C:37]2[C:32]([C:33]([NH:39][C:40]3[CH:45]=[C:44]([O:46][C:47]([O:49][CH3:50])=[O:48])[C:43]([CH3:51])=[CH:42][C:41]=3[F:52])=[N:34][CH:35]=[N:36]2)=[CH:31][CH:30]=1>N1C=CC=CC=1>[F:52][C:41]1[CH:42]=[C:43]([CH3:51])[C:44]([O:46][C:47]([O:49][CH3:50])=[O:48])=[CH:45][C:40]=1[NH:39][C:33]1[C:32]2[C:37](=[CH:38][C:29]([NH:28][C:24](=[O:26])[CH2:23][CH2:22][N:19]3[CH2:18][CH2:17][O:16][CH2:21][CH2:20]3)=[CH:30][CH:31]=2)[N:36]=[CH:35][N:34]=1

Komponenten

5

Edukt 3

HCID 10868Dicyclohexylcarbodiimide2×HCID 4108133-(Morpholin-4-yl)propanoic acid2×HCID 226250847-Amino4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)quinazoline hydrochloride

Produkt 1

HCID 212603554-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-(3-morpholinopropionamido)quinazolineAusbeute 48,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

1,3-Dicyclohexylcarbodiimide (343 mg, 1.6 mmol) was added to a suspension of 3-morpholinopropionic acid (325 mg, 1.6 mmol) in pyridine (12 ml) and the mixture stirred for 10 minutes. 7-Amino-4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)quinazoline hydrochloride (370 mg, 0.97 mmol), (prepared as described for the starting material in Example 29), was added and the mixture stirred for 32 hours. 3-Morpholinopropionic acid (57 mg, 0.29 mmol) followed by 1,3-dicyclohexylcarbodiimide (100 mg, 0.48 mmol) was added and the mixture stirred for a further 18 hours. The solvent was removed by evaporation, the residue partitioned between water and ethyl acetate and the aqueous layer adjusted to pH8 with a saturated solution of sodium hydrogen carbonate. The organic layer was separated, washed with brine, dried (MgSO4), and the solvent removed by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-(3-morpholinopropionamido)quinazoline (226 mg, 48%) as a white solid.

Aufarbeitung

  1. additionwas added
  2. stirringthe mixture stirred for 32 hours
  3. additionwas added
  4. stirringthe mixture stirred for a further 18 hours
  5. customThe solvent was removed by evaporation
  6. customthe residue partitioned between water and ethyl acetate
  7. customThe organic layer was separated
  8. washwashed with brine
  9. dry with materialdried (MgSO4)
  10. customthe solvent removed by evaporation
  11. customThe residue was purified by column chromatography
  12. washeluting with methylene chloride/methanol (95/5)

Quellen und Nachweise

ORD-Eintrag
ord-19dc0f0f168a4f5ab0ebf4be2422b5f0
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06184225B2

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