Potassium Carbonate → 2-[4-(4-Benzylaminosulfonylmethylbenzyl)-phenyl]amino-imidazoline

HRID 634818

Reaktionsgleichung

Reaktionsgleichung von HRID 634818
[CH2:1]([NH:8][S:9]([CH2:12][C:13]1[CH:26]=[CH:25][C:16]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=2)=[CH:15][CH:14]=1)(=[O:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:28]1[NH:29][CH2:30][CH2:31][N:32]=1.C(=O)([O-])[O-].[K+].[K+]>CC(O)C>[CH2:1]([NH:8][S:9]([CH2:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([NH:24][C:28]3[NH:32][CH2:31][CH2:30][N:29]=3)=[CH:22][CH:23]=2)=[CH:25][CH:26]=1)(=[O:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 2362362-Chloro-4,5-dihydroimidazoleHCID 218769594-(4-Benzylaminosulfonylmethylbenzyl)-phenylamine

Produkt 1

HCID 120943882-[4-(4-Benzylaminosulfonylmethylbenzyl)-phenyl]amino-imidazoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(4-benzylaminosulfonylmethylbenzyl)-phenylamine (39 mg) and 2-chloro-imidazoline base (1 eq ) in 2-propanol was heated under reflux for 16 hours. A dilute solution of potassium carbonate was poured into the mixture and extracted with dichloromethane (4×15 mL). Solvents were evaported to give 2-[4-(4-benzylaminosulfonylmethylbenzyl)-phenyl]amino-imidazoline as a solid (41.7 mg), m.p. 115-118° C.; Analysis for C24H25CIN4O2S.H2O: Calc.: C, 58.94; H, 5.98; N, 11.46; Found: C, 59.01; H, 5.91; N, 11.30.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. extractionextracted with dichloromethane (4×15 mL)

Quellen und Nachweise

ORD-Eintrag
ord-fd75b58aa5dc4d7084a7da2a352bbd66
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06184242B2

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