Hydrochloric Acid → N-ethyl 2,3-dihydroxycyclopentane carboxamide dihydrochloride hydrate
Reaktionsgleichung
[ClH:1].[CH2:2]([NH:4][C:5]([CH:7]1[CH2:11][CH2:10][CH:9]([OH:12])[CH:8]1[OH:13])=[O:6])[CH3:3]>>[OH2:6].[ClH:1].[ClH:1].[CH2:2]([NH:4][C:5]([CH:7]1[CH2:11][CH2:10][CH:9]([OH:12])[CH:8]1[OH:13])=[O:6])[CH3:3]Komponenten
3
Versuchsvorschrift
The zinc metal and any other insoluble impurities are then removed by filtration of the contents of vessel and the filtrate is collected in another reaction vessel. Acid hydrolysis of [3aR-[3aα,4α,6a(R*),6aα]]-6-[4-[[1-[(3-chlorothien-2-yl)methyl]propyl]amino]-3-aminopyrid-2-ylamino] N-ethyl tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxole-4-carboxamide (XIII) is then effected by adding concentrated HCl to the second reaction vessel and heating until conversion to [1S-[1α,2β,3β,4α(S*)]]-4-[3-amino-4-[[1-[3-chlorothien-2-yl)methyl]propyl]amino]pyrid-2-ylamino] N-ethyl 2,3-dihydroxycyclopentanecarboxamide (XIII) is essentially complete. Cooling of the second reaction vessel results in crystallization of [1S-[1α,2β,3β,4α(S*)]]-4-[3-amino-4-[[1-[3-chlorothien-2-yl)methyl]propyl]amino]pyrid-2-ylamino] N-ethyl 2,3-dihydroxycyclopentane carboxamide dihydrochloride hydrate which is isolated by filtration.