Thionyl Chloride → 3,3-Difluorooxolane-2,5-dione

HRID 635220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 635220
[F:1][C:2]([F:10])([CH2:6][C:7]([OH:9])=[O:8])[C:3](O)=[O:4].S(Cl)(Cl)=O>C1C=CC=CC=1>[F:1][C:2]1([F:10])[CH2:6][C:7](=[O:9])[O:8][C:3]1=[O:4]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 695812,2-Difluorosuccinic acid

Produkt 1

HCID 131892433,3-Difluorooxolane-2,5-dioneAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

A mixture of 2,2-difluorosuccinic acid (1.15 g, 7.46 mmol), thionyl chloride (4 mL, 20.6 mmol) and benzene (4 mL) was heated at reflux for 2.5 h. The mixture was filtered and the filtrate was concentrated to afford the title product as an oil that crystallized on standing (838 mg, 6.16 mmol, 83% yield).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 2.5 h
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-db005c9bb6ce4d098b8d9edbf43c09ff
Quelldatensatz
uspto-grants-2001_02
Patentnummer
US06187789B1

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