Cycloheptanone Oxime → 3-(3-(4-(4-methylphenyl)piperidin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole

HRID 635277

Reaktionsgleichung

[C:1]1(=[N:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][C:26](OCC)=O)[CH2:19][CH2:18]2)=[CH:13][CH:12]=1>>[CH3:10][C:11]1[CH:12]=[CH:13][C:14]([CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][C:26]3[O:9][N:8]=[C:1]4[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]=34)[CH2:19][CH2:18]2)=[CH:15][CH:16]=1

Komponenten

Edukt 2

HCID 137457Cycloheptanone Oxime

HCID 17773197Ethyl 4-(4-(4-methylphenyl)piperidin-1-yl)-n-butyrate

Produkt 1

HCID 599393693-(3-(4-(4-methylphenyl)piperidin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole

Versuchsvorschrift

By the same reaction and treatment as in Example 48 using cycloheptanone oxime and ethyl 4-(4-(4-methylphenyl)piperidin-1-yl)-n-butyrate, 3-(3-(4-(4-methylphenyl)piperidin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole is obtained.

Quellen und Nachweise

ORD-Eintrag: ord-fe4e95b459654f94afec01057a61c023
Quelldatensatz: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06187774B1

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