Hydrochloric Acid → 3-Chloro-4-fluorobenzoic acid

HRID 635543

Reaktionsgleichung

C[C:2]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([Cl:11])[CH:5]=1)=[O:3].Br[O-].[Na+].S([O-])(O)=[O:16].[Na+].Cl>>[Cl:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[F:10])[C:2]([OH:3])=[O:16]

Komponenten

Edukt 4

HCID 313Hydrochloric Acid

HCID 5204223'-Chloro-4'-fluoroacetophenone

HCID 23665763Sodium Bisulfite

HCID 23673712Sodium hypobromite

Produkt 1

HCID 5209893-Chloro-4-fluorobenzoic acidAusbeute 74 %

Versuchsvorschrift

The 3-chloro-4-fluoroacetophenone is then reacted with an aqueous solution of sodium hypobromite, the aqeuous phase is treated with sodium hydrogensulfite and acidified with hydrochloric acid, and the precipitated product is recrystallized from benzene. 3-Chloro-4-fluorobenzoic acid obtained in a yield of 74%.

Aufarbeitung

customthe precipitated product is recrystallized from benzene

Quellen und Nachweise

ORD-Eintrag: ord-d546c0be93c5496da77831fb43df7de5
Quelldatensatz: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06187952B1

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