Tyrosine Methyl Ester → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tyrosine Methyl Ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Tyrosine Methyl Ester	HCID 70652	—
Edukt	(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid	HCID 12135350	—
Produkt	N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tyrosine Methyl Ester	HCID 10180420	—

Reaktionsschritte

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-tyrosine methyl ester (Bachem), the title compound was prepared as a solid (mp=85-88° C.). The reaction was monitored by tlc (Rf=0.27 in 50% EtOAc/hexanes) and the product was purified by silica gel column chromatography.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06191166B1
Quelldatensatz	uspto-grants-2001_02
ORD ID	ord-333af5f0f1b840e18c6abaf4d8e71dba
Quellennotiz	uspto-grants-2001_02