Reaktionsgleichung
[NH2:1][C:2]1NCC2C(=CC=C(Cl)C=2Cl)N=1.ClC1C=CC=C(Cl)C=1Cl.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[C:26](Cl)[C:25]=1[Cl:34].C([Cu])#N>>[Cl:34][C:25]1[C:24]([Cl:23])=[CH:29][CH:28]=[C:27]([N+:30]([O-:32])=[O:31])[C:26]=1[C:2]#[N:1]Komponenten
5
Versuchsvorschrift
As shown below in the Examples, a preferred process is set forth for making 2-amino-5,6-dichloro-3,4-dihydroquinazoline from commercially available starting materials. In one process 1,2,3-trichlorobenzene is used as the starting material and is nitrated using, for example, nitric/sulfuric acids to form 1,2,3-trichloro-4-nitrobenzene. This compound is then reacted with a cyanating agent such as CuCN to form 2,3-dichloro-6-nitrobenzonitrile. The nitrile is then reacted under reducing conditions using for example B2H6 to form 2,3-dichloro-6-nitrobenzylamine HCl which is then reduced and reacted with CNX to form the desired compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-ef58309f84144dda8660277dd5c84248
- Quelldatensatz
- uspto-grants-2001_02
- Patentnummer
- US06194420B1
Verknüpfte Notizen
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