4-Methylpiperidine-1-sulfonyl chloride → HCID 70225375, Verbindung
Reaktionsgleichung
[CH:1]12[CH:6]([N:7]3[C:11](=[O:12])[C:10]([CH2:20][C:21]4[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=4)([CH2:13][C:14]4[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=4)[NH:9][C:8]3=[CH:27][C:28]([C:30]3[CH:37]=[CH:36][C:33]([C:34]#[N:35])=[CH:32][CH:31]=3)=[O:29])[CH:5]1[CH2:4][NH:3][CH2:2]2.[CH3:38][CH:39]1[CH2:44][CH2:43][N:42]([S:45](Cl)(=[O:47])=[O:46])[CH2:41][CH2:40]1>>[CH3:38][CH:39]1[CH2:44][CH2:43][N:42]([S:45]([N:3]2[CH2:4][CH:5]3[CH:1]([CH:6]3[N:7]3[C:11](=[O:12])[C:10]([CH2:20][C:21]4[CH:22]=[CH:23][N:24]=[CH:25][CH:26]=4)([CH2:13][C:14]4[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=4)[NH:9][C:8]3=[CH:27][C:28]([C:30]3[CH:31]=[CH:32][C:33]([C:34]#[N:35])=[CH:36][CH:37]=3)=[O:29])[CH2:2]2)(=[O:47])=[O:46])[CH2:41][CH2:40]1Komponenten
3
Versuchsvorschrift
According to the procedure of Example 13, 4-{[1-(3-aza-bicyclo[3.1.0]hex-6-yl)-5-oxo-4,4-bis-pyridin-4-ylmethyl-imidazolidin-2-ylidene]-acetyl}-benzonitrile (50 mg, 0.102 mmol) and 4-methyl-piperidine-1-sulfonyl chloride (60.2 mg, 0.306 mmol) were reacted to generate the title compound as an off-white solid (62 mg, 0.095 mmol, 93% yield).
Aufarbeitung
- customwere reacted