Trifluoroacetic acid → 3-Methylmorpholine-3-carboxylic acid

HRID 63685Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 63685
[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1([C:15]([OH:17])=[O:16])[CH2:7][O:6][CH2:5][CH2:4][NH:3]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 223091424-((Tert-butoxy)carbonyl)-3-methylmorpholine-3-carboxylic acid

Produkt 1

HCID 836796483-Methylmorpholine-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 3-methyl-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-3-carboxylic acid (Accela ChemBio Co., Ltd., CAS: 1052680-53-1, 50 mg, 0.2.0 mmol) in DCM (1 ml) was added trifluoroacetic acid (1 mL) dropwise at room temperature. The resulting mixture was stirred at room temperature for one hour and then concentrated under the vacuum. The residue was used directly in next step without further purification,

Aufarbeitung

  1. concentrationconcentrated under the vacuum
  2. customThe residue was used directly in next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-908386cd59a441989ed9d68678a1eedf
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447086B2

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