Hydrochloric Acid → alpha-Cyclopentyl-p-hydroxybutyrophenone

HRID 637376

Reaktionsgleichung

Reaktionsgleichung von HRID 637376
[CH:1]1([CH:6]([CH2:17][CH3:18])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl-].[Cl-].[Cl-].[Al+3].Cl>C1C=CC=CC=1>[CH:1]1([CH:6]([CH2:17][CH3:18])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 13175264HCID 13175264, Verbindung

Produkt 1

HCID 13175265alpha-Cyclopentyl-p-hydroxybutyrophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

The mixture of 4.9 g (0.02 mol) of α-cyclopentyl-p-methoxy butyrophenone, 8.0 g (0.06 mol) of aluminium trichloride and 60 ml of benzene was refluxed for 3 hours. Dilute hydrochloric acid was added, the layers separated and the organic layer washed with water. The product was extracted with 2M sodium hydroxide. The alkaline solution was made acidic. The product was extracted with methylene chloride, dried and the solvent evaporated. The residue 4.1 g (0.018 mol, 88%) was crystallized from petroleum ether. Mp. 75°-78° C.

Aufarbeitung

  1. temperaturewas refluxed for 3 hours
  2. customthe layers separated
  3. washthe organic layer washed with water
  4. extractionThe product was extracted with 2M sodium hydroxide
  5. extractionThe product was extracted with methylene chloride
  6. customdried
  7. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8dadc59f99e94a73b861f46460cb8c9b
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04556677

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