Sodium Cyanide → 2-(2-Fluorophenyl)propanenitrile

HRID 637613Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 637613
[C-:1]#[N:2].[Na+].[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[CH:7](Cl)[CH3:8]>CS(C)=O>[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[CH:7]([C:1]#[N:2])[CH3:8]

Komponenten

4

Edukt 2

HCID 8929Sodium CyanideHCID 135643251-(1-Chloroethyl)-2-fluorobenzene

Produkt 1

HCID 133880122-(2-Fluorophenyl)propanenitrileAusbeute 85,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

In 300 ml of dimethyl sulfoxide was dissolved 35 g of sodium cyanide by heating at 90° C., and 45 g of 2-fluoro-α-methylbenzyl chloride was added. The mixture was stirred at 90° C. for 4 hours, and then cooled. Ice-water was added and the mixture was extracted with n-hexane. The n-hexane layer was washed with water and dried over anhydrous magnesium sulfate and the solvent was evaporated off. The residue obtained was purified by distillation under reduced pressure to afford 36 g of 2-fluoro-α-methylbenzyl cyanide, b.p.0.5 55° C.

Aufarbeitung

  1. temperaturecooled
  2. extractionthe mixture was extracted with n-hexane
  3. washThe n-hexane layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated off
  6. customThe residue obtained
  7. distillationwas purified by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b4950e3dd7e146fd8c32b508fa2be13f
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04557871

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