Aluminum Stearate → Apraclonidine

HRID 637716

Reaktionsgleichung

Reaktionsgleichung von HRID 637716
C([O-])(=O)CCCCCCCCCCCCCCCCC.[Al+3].C([O-])(=O)CCCCCCCCCCCCCCCCC.C([O-])(=O)CCCCCCCCCCCCCCCCC.[CH2:62]1[NH:66][C:65]([NH:67][C:68]2[C:73]([Cl:74])=[CH:72][C:71]([NH2:75])=[CH:70][C:69]=2[Cl:76])=[N:64][CH2:63]1.Cl.Cl>>[CH2:62]1[NH:66][C:65]([NH:67][C:68]2[C:73]([Cl:74])=[CH:72][C:71]([NH2:75])=[CH:70][C:69]=2[Cl:76])=[N:64][CH2:63]1

Komponenten

3

Edukt 2

HCID 12496Aluminum StearateHCID 21479682Apraclonidine dihydrochloride

Produkt 1

HCID 2216Apraclonidine

Reaktionsbedingungen

Temperatur
115 °C

Versuchsvorschrift

The aluminum stearate was dispersed with stirring in a portion of the sunflower oil heated to 115° C. The dispersion was added to the rest of the sunflower oil heated to 140° C. The gel was stirred at 130° C. for 15 minutes and then allowed to cool without stirring to room temperature. The milled p-Amino Clonidine dihydrochloride was dispersed in the cooled gel base and then passed through a colloid mill to produce a fine, homogenous dispersion. The dispersion was filled into plastic bottles fitted with a dosing pump.

Aufarbeitung

  1. additionThe dispersion was added to the rest of the sunflower oil
  2. temperatureheated to 140° C
  3. stirringThe gel was stirred at 130° C. for 15 minutes
  4. temperatureto cool
  5. stirringwithout stirring to room temperature
  6. customto produce a fine, homogenous dispersion
  7. additionThe dispersion was filled into plastic bottles
  8. customfitted with a dosing pump

Quellen und Nachweise

ORD-Eintrag
ord-c167cef229d340d2aba763d3cc9a83b8
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04558063

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