HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochlorothiazide → 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochlorothiazide | HCID 3639 | — |
| Edukt | 1,2-Dibromoethane | HCID 7839 | — |
| Edukt | Cesium carbonate | HCID 10796 | — |
| Edukt | Benzylbromoacetate | HCID 21881508 | — |
| Produkt | 2-(2-Bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine | HCID 14280971 | — |
Reaktionsschritte
Treat 6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine with Cs2CO3 and substitute 1,2-dibromoethane for benzylbromoacetate in the procedure of Example 6, step A to obtain 2-(2-bromoethyl)-6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04559340 |
| Quelldatensatz | uspto-grants-1985_12 |
| ORD ID | ord-23834e8178da43bf8cb1ffdc8652c51f |
| Quellennotiz | uspto-grants-1985_12 |