Sodium Hydroxide → 4,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidine

HRID 637930

Reaktionsgleichung

Reaktionsgleichung von HRID 637930
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[OH-].[Na+].[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1>C(O)C>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][S:3][C:2]2[N:4]=[C:5]([OH:6])[CH:7]=[C:8]([OH:9])[N:1]=2)=[CH:16][CH:15]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 699934-Methyloxybenzyl chlorideHCID 2723628Thiobarbituric acid

Produkt 1

HCID 1784917094,6-Dihydroxy-2-(4-methoxybenzylsulfanyl)pyrimidineAusbeute 54,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a suspension of thiobarbituric acid (15 g) in 50% ethanol (180 ml) are added a solution of NaOH (5.1 g) in 50% ethanol (75 ml) and p-methoxybenzyl chloride (18.7 g). The mixture is heated under stirring for 60' at 60° C.; then it is cooled and the solid is filtered by suction, washed with water; then dried over CaCl2, yielding 15 g of 2-p-methoxy-benzylthio-4,6-dihydroxypyrimidine.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperaturethen it is cooled
  3. filtrationthe solid is filtered by suction
  4. washwashed with water
  5. dry with materialthen dried over CaCl2

Quellen und Nachweise

ORD-Eintrag
ord-5d6de63010204f47b9d61cc676dd9f97
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04559345

Verknüpfte Notizen

Wird geladen…