2,3-Dimethylaniline → 2-p-Methoxybenzylthio-4-chloro-6-(2,3-xylidino)-pyrimidine

Beteiligte Stoffe

Reaktionsschritte

To a solution of 2-p-methoxybenzylthio-4,6-dichloro-pyrimidine (19.8 g) in acetonitrile (100 l) is added 2,3-xylidine (16 ml) and the resulting mixture is refluxed for 36 hours. The solid is filtered, washed with a little amount of acetonitrile, then the filtrate is concentrated to dryness. The residue is purified by chromatography on silica-gel. 17 g of the desired product are obtained. M.p. 118°-119° C. (benzene/hexane).

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