2,3-Dimethylaniline → 6-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

HRID 637938Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 637938
[CH2:1]([S:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[C:12]([Cl:17])[N:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C([O-])([O-])=O.[Na+].[Na+].[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=1[CH3:32]>C(O)C>[CH2:1]([S:9][C:10]1[N:11]=[C:12]([Cl:17])[CH:13]=[C:14]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=2[CH3:32])[N:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

5

Edukt 3

HCID 68932,3-DimethylanilineHCID 10340Sodium CarbonateHCID 134137254,6-Dichloro-2-(octylsulfanyl)pyrimidine

Produkt 1

HCID 134137406-Chloro-N-(2,3-dimethylphenyl)-2-(octylsulfanyl)pyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 2-octylthio-4,6-dichloropyrimidine (3 g) in ethanol (25 ml), 2,3-xylidine (1,5 ml) and anhydrous Na2CO3 (1.25 g) are added; the mixture is refluxed for 20 hours. The residue is hot filtered and the solvent is evaporated. The residue is purified by chromathography on silica gel, yielding 1.9 g of 2-octylthio-4-chloro-6-(2,3-xylidino)-pyrimidine (III, 35).

Aufarbeitung

  1. temperaturethe mixture is refluxed for 20 hours
  2. filtrationThe residue is hot filtered
  3. customthe solvent is evaporated
  4. customThe residue is purified by chromathography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-f914c1fe74144309b8969f58fca44d9d
Quelldatensatz
uspto-grants-1985_12
Patentnummer
US04559345

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