Reaktionsgleichung
N[NH-].[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]2[C:13]([O:15][C:16](=[O:17])[C:4]=12)=[O:14].[C:18]([C:21]1[C:30]([C:31](O)=O)=[CH:29]C2C(=CC=CC=2)[N:22]=1)(=[O:20])[NH2:19].N1C=CC=C[CH:35]=1>>[C:18]([C:21]([NH:22][C:16]([C:4]1[C:5]([C:13]([OH:15])=[O:14])=[CH:6][C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:3]=1)=[O:17])([CH3:35])[CH:30]([CH3:31])[CH3:29])(=[O:20])[NH2:19]Komponenten
5
Versuchsvorschrift
The aminoamide (24.25 mmol) is added over a two hour period to a solution of 2,3-quinolinedicarboxylic anhydride (20.06 mmol) in pyridine (100 mL) while maintaining the reaction mixture at room temperature. The mixture is allowed to stir at room temperature for one-half hour. Analysis of the isomer distribution of the reaction products by high performance liquid chromatography shows an 8.9/1 ratio of the desired 2-carbamoyl-3-quinolinecarboxylic acid.
Quellen und Nachweise
- ORD-Eintrag
- ord-526a40f85ffe40aaa4af8111792f6707
- Quelldatensatz
- uspto-grants-1985_12
- Patentnummer
- US04562257
Verknüpfte Notizen
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