Hydrochloric Acid → HCID 66811347, Verbindung

HRID 638712

Reaktionsgleichung

Reaktionsgleichung von HRID 638712
C[O:2][C:3](=[O:20])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]C(=O)C)=[CH:12][CH:11]=1.[ClH:21]>>[ClH:21].[NH2:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 497644916-(4-Acetylaminophenoxy)-hexanoic acid methyl ester

Produkt 1

HCID 66811347HCID 66811347, VerbindungAusbeute 55,6 %

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

Aufarbeitung

  1. temperaturewas refluxed for 48 hours
  2. distillationExcess concentrated hydrochloric acid was distilled off in vacuum
  3. filtrationfiltered hot
  4. filtrationfiltered
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-aaaf3cd83c2b4643bc5b4bb389e8ae5a
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691364B2

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