2,4-Dimethylbenzylamine → HCID 16038903, Verbindung

HRID 639248Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639248
ClC(Cl)(Cl)[C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([O:34][CH3:35])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4].[CH3:38][C:39]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][C:40]=1[CH2:41][NH2:42]>>[CH3:38][C:39]1[CH:46]=[C:45]([CH3:47])[CH:44]=[CH:43][C:40]=1[CH2:41][NH:42][C:3]([C:5]1[N:14]2[C:8]([CH2:9][N:10]([C:19]([C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[CH3:33])=[C:23]([O:34][CH3:35])[CH:22]=3)=[O:20])[C:11]3[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=3[CH2:13]2)=[CH:7][CH:6]=1)=[O:4]

Komponenten

3

Edukt 2

HCID 667612,4-DimethylbenzylamineHCID 160388252,2,2-Trichloro-1-{10-[(2-methoxy-2'-methyl-1,1'-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone

Produkt 1

HCID 16038903HCID 16038903, Verbindung

Versuchsvorschrift

The title compound was prepared in the manner of Example 36 from 2,2,2-trichloro-1-{10-[(2-methoxy-2′-methyl-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 35 and 2,4-dimethyl benzylamine, m.p. 161-162° C. MS [(+)ESI, m/z]: 570 [M+H]+ Anal. Calcd for C37H35N3O3: C, 78.01; H, 6.19; N, 7.38. Found: C, 77.86; H, 6.40; N, 7.20.

Quellen und Nachweise

ORD-Eintrag
ord-fa1c79121dab45aca1f229618619ae9c
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691848B2

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