Methyl 2-amino-2-ethylbutanoate → 2-{[5-Butylamino-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carbonyl]-amino}-2-ethyl-butyric acid methyl ester

HRID 639335

Reaktionsgleichung

Reaktionsgleichung von HRID 639335
OC[C@@H](NC(C1C=NC(N2CCCC2)=C(OCCC)N=1)=O)CC(C)C.[CH2:26]([NH:30][C:31]1[N:32]=[CH:33][C:34]([C:43]([OH:45])=O)=[N:35][C:36]=1[O:37][CH2:38][C:39]([F:42])([F:41])[F:40])[CH2:27][CH2:28][CH3:29].[CH3:46][O:47][C:48](=[O:55])[C:49]([NH2:54])([CH2:52][CH3:53])[CH2:50][CH3:51]>>[CH3:46][O:47][C:48](=[O:55])[C:49]([NH:54][C:43]([C:34]1[CH:33]=[N:32][C:31]([NH:30][CH2:26][CH2:27][CH2:28][CH3:29])=[C:36]([O:37][CH2:38][C:39]([F:40])([F:41])[F:42])[N:35]=1)=[O:45])([CH2:52][CH3:53])[CH2:50][CH3:51]

Komponenten

4

Edukt 3

HCID 13412527Methyl 2-amino-2-ethylbutanoateHCID 248312586-Propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amideHCID 685666105-Butylamino-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid

Produkt 1

HCID 248319032-{[5-Butylamino-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carbonyl]-amino}-2-ethyl-butyric acid methyl ester

Versuchsvorschrift

In analogy to the procedure described for the synthesis of 6-propoxy-5-pyrrolidin-1-yl-pyrazine-2-carboxylic acid ((S)-1-hydroxymethyl-3-methyl-butyl)-amide (example 10, step d) the title compounds was prepared from 5-butylamino-6-(2,2,2-trifluoro-ethoxy)-pyrazine-2-carboxylic acid and 2-amino-2-ethyl-butyric acid methyl ester (European Journal of Medicinal Chemistry 1984, 19, 261). m/z (ES+): 421.1 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-8223daedbe954ae1ba1236d69f2e15ac
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691863B2

Verknüpfte Notizen

Wird geladen…