Hydrogen Bromide → 2-(3-tert-Butyl-phenylamino)-quinoxalin-6-ol

HRID 639365Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639365
[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]2[CH:21]=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22]C)[CH:18]=3)[N:13]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].Br>>[C:1]([C:5]1[CH:6]=[C:7]([NH:11][C:12]2[CH:21]=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([OH:22])[CH:18]=3)[N:13]=2)[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 260Hydrogen BromideHCID 59254854(3-tert-Butyl-phenyl)-(6-methoxy-quinoxalin-2-yl)-amine

Produkt 1

HCID 1361450542-(3-tert-Butyl-phenylamino)-quinoxalin-6-ol

Versuchsvorschrift

The mixture of (3-tert-Butyl-phenyl)-(6-methoxy-quinoxalin-2-yl)-amine and hydrobromic acid (48%) was subjected to the microwave at 140° C. for 6 mins. to yield the desired product. The mixture was neutralized with sodium bicarbonate solution and taken in ethyl acetate. The organic layer was washed with water and brine, concentrated, and purified on silica gel.

Quellen und Nachweise

ORD-Eintrag
ord-6820880ed5a74296870402dda3a82ecc
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691866B2

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