Triethylamine → HCID 11384330, Verbindung

Reaktionsgleichung

[CH3:1][CH:2]([S:4](Cl)(=[O:6])=[O:5])[CH3:3].C(N(CC)CC)C.Cl.[C@@H:16]12[CH2:23][NH:22][CH2:21][C@@H:20]1[CH2:19][N:18]([C:24]1[NH:25][C:26]3[CH:32]=[C:31]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH:30]=[CH:29][C:27]=3[N:28]=1)[CH2:17]2>C1COCC1>[CH:2]([S:4]([N:22]1[CH2:21][C@@H:20]2[C@@H:16]([CH2:17][N:18]([C:24]3[NH:25][C:26]4[CH:32]=[C:31]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)[CH:30]=[CH:29][C:27]=4[N:28]=3)[CH2:19]2)[CH2:23]1)(=[O:6])=[O:5])([CH3:3])[CH3:1]

Komponenten

Versuchsvorschrift

2-Propanesulfonyl chloride and triethylamine were added to the THF suspension (5 mL) containing 2-(cis-3,7-diazabicyclo[3.3.0]oct-3-yl)-5-phenylbenzimidazole hydrochloride (26 mg) at room temperature, followed by stirring for 15 min. The reaction mixture was concentrated under reduced pressure, and the residue was separated and purified on a collective thin-layer chromatograph (chloroform:methanol=10:1) to give the title compound (12 mg).