4-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine → 2-(piperidin-4-yl)-1lambda6,2-thiazolidine-1,1-dione

HRID 639442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639442
[O:1]=[S:2]1(=[O:20])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][N:10](CC2C=CC=CC=2)[CH2:9][CH2:8]1>[OH-].[Pd+2].[OH-].CO>[O:20]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

Komponenten

4

Edukt 1

HCID 462231014-(1,1-Dioxido-2-isothiazolidinyl)-1-(phenylmethyl)piperidine

Produkt 1

HCID 532560872-(piperidin-4-yl)-1lambda6,2-thiazolidine-1,1-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

20% Palladium hydroxide (100 mg) was added to the methanol solution (5 mL) containing 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-1-benzylpiperidine (252 mg) at 0° C., followed by stirring at room temperature for 5 hrs. under a hydrogen atmosphere. The reaction mixture was filtered to remove the palladium catalyst, followed by concentration under reduced pressure to give the title compound.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customto remove the palladium catalyst
  3. concentrationfollowed by concentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8989cc46dee44dd7a73021652d3582be
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691860B2

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