2-Furancarboxylic acid, hydrazide → N'-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)furan-2-carbohydrazide

HRID 639479Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639479
Cl[C:2]1[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([NH2:8])[N:7]=1.[O:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]([NH:19][NH2:20])=[O:18]>C(O)CCC>[NH2:8][C:6]1[N:7]=[C:2]([NH:20][NH:19][C:17]([C:13]2[O:12][CH:16]=[CH:15][CH:14]=2)=[O:18])[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=1

Komponenten

4

Edukt 2

HCID 187312-Furancarboxylic acid, hydrazideHCID 53244134-chloro-7H-pyrrolo(2,3-d)pyrimidin-2-amine

Produkt 1

HCID 68413686N'-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)furan-2-carbohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (0.5 g, 2 96 mmol) and 2-furoic acid hydrazide (0.76 g, 6.0 mmol) are taken into 30 mL of n-butanol. The mixture is stirred at 120° C. under N2 for 2 h. The solvent is evaporated in vacuum and the residue is triturated with water and filtered to afford compound N′-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)furan-2-carbohydrazide: LC/MS (M+1=259.32). This material is used in the next step without further purification.

Aufarbeitung

  1. customThe solvent is evaporated in vacuum
  2. customthe residue is triturated with water
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-9c18393e120b4d02bda899e162f1e760
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691869B2

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