(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol → 4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

HRID 639795Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639795
[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH2:14][OH:15])[CH3:2]>[O-2].[O-2].[Mn+4].ClCCl>[CH2:1]([N:3]1[C:7]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]1[CH:14]=[O:15])[CH3:2]

Komponenten

4

Edukt 1

HCID 68431190(4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)methanol

Produkt 1

HCID 860676734-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Dichloromethane (4 mL) was added to a vial containing (4-ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-methanol (56.7 mg, 0.279 mmol) and manganese dioxide (364.3 mg, 4.19 mmol) was added. The vial was sealed and the reaction was allowed to stir for two hours. The reaction was filtered through celite and concentrated to yield the title compound. 1H NMR (CDCl3) δ (ppm): 10.21 (s, 1H), 8.88 (d, 2H), 7.63 (d, 2H), 4.45 (q, 2H), 1.48 (t, 3H).

Aufarbeitung

  1. additionwas added
  2. customThe vial was sealed
  3. filtrationThe reaction was filtered through celite and
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a3d56a31fdad4b38b1c27b576c108d9a
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691892B2

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