1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine → 3-[(Dimethylamino)methyl]-6-methoxy-4-phenylisoquinoline-1-carbonitrile

HRID 639877Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 639877
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:4]([CH2:20][N:21]([CH3:23])[CH3:22])[N:3]=1.[C:24]([Cu])#[N:25]>CS(C)=O>[CH3:22][N:21]([CH2:20][C:4]1[N:3]=[C:2]([C:24]#[N:25])[C:11]2[C:6]([C:5]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH3:23]

Komponenten

4

Edukt 2

HCID 117389161-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamineHCID 178418546HCID 178418546, Verbindung

Produkt 1

HCID 112555843-[(Dimethylamino)methyl]-6-methoxy-4-phenylisoquinoline-1-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

A mixture of 1-(1-chloro-6-methoxy-4-phenylisoquinolin-3-yl)-N,N-dimethylmethanamine (31 mg), 1 mL DMSO, and 16 mg CuCN was stirred at 140 C for 3 h. The solution was cooled and purified directly by reverse-phase HPLC to give the titled compound.

Aufarbeitung

  1. temperatureThe solution was cooled
  2. custompurified directly by reverse-phase HPLC

Quellen und Nachweise

ORD-Eintrag
ord-5b91032d9a864e44971efc9f0402ff61
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691879B2

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