Potassium Carbonate → 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole

HRID 64053

Reaktionsgleichung

Reaktionsgleichung von HRID 64053
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:14][CH:15]1[CH2:17][CH2:16]1>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:14][CH:15]2[CH2:17][CH2:16]2)[CH:6]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 163754-BromopyrazoleHCID 81503Bromomethylcyclopropane

Produkt 1

HCID 510722584-Bromo-1-(cyclopropylmethyl)-1H-pyrazoleAusbeute 109,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 4-bromo-1H-pyrazole (0.1 g, 0.68 mmol) in DMF (20 ml) were added K2CO3 (0.19 g, 1.36 mmol, 2 eq.) and (bromomethyl)cyclopropane (92 mg, 0.68 mmol, 1 eq.). The mixture was stirred at RT for 4 h. The mixture was quenched and extracted as in Intermediate Example 5(c). The solvent was distilled off to afford the crude product (0.15 g).

Aufarbeitung

  1. customThe mixture was quenched
  2. extractionextracted as in Intermediate Example 5(c)
  3. distillationThe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-a167ce228617490a96ee8259ff7c99af
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447091B2

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