2-Benzyl-5-[1,3]dioxolan-2-yl-pyridine → 6-Benzyl-pyridine-3-carbaldehyde

HRID 640540

Reaktionsgleichung

Reaktionsgleichung von HRID 640540
[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2OCC[O:15]2)=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl>[CH2:1]([C:8]1[N:9]=[CH:10][C:11]([CH:14]=[O:15])=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 592551082-Benzyl-5-[1,3]dioxolan-2-yl-pyridine

Produkt 1

HCID 216983476-Benzyl-pyridine-3-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2-Benzyl-5-[1,3]dioxolan-2-yl-pyridine (7.3 g, 30 mmol) described in Manufacturing Example 210-1-3 and 2 N hydrochloric acid (100 mL) were stirred for 55 minutes at 100° C. The reaction solution was cooled to room temperature and partitioned into ethyl acetate and a 5 N sodium hydroxide solution (40 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, and filtered.

Aufarbeitung

  1. temperatureThe reaction solution was cooled to room temperature
  2. custompartitioned into ethyl acetate
  3. customThe organic layer was separated
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-549e0a2da0cb42c781b173e9e098a100
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07691882B2

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