1-Pyrrolidineacetic acid, ethyl ester → Pyrrolidin-1-ylacetic acid

HRID 64066

Reaktionsgleichung

Reaktionsgleichung von HRID 64066
[N:1]1([CH2:6][C:7]([O:9]CC)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]([OH:9])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 2109961-Pyrrolidineacetic acid, ethyl ester

Produkt 1

HCID 414564Pyrrolidin-1-ylacetic acidAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

The solution of ethyl 2-(pyrrolidin-1-yl)acetate (2 g, 12.7 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 91% yield (1.5 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H+] (rt: 0.26 min).

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 91% yield (1.5 g)
  6. customObserved mass 130.1 [M+H+] (rt: 0.26 min)

Quellen und Nachweise

ORD-Eintrag
ord-4fed8b6380b94254a92f74f824b0f9b3
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447091B2

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