1-Piperidineacetic acid, ethyl ester → Piperidin-1-yl-acetic acid

HRID 64070

Reaktionsgleichung

Reaktionsgleichung von HRID 64070
[N:1]1([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 6434661-Piperidineacetic acid, ethyl ester

Produkt 1

HCID 201097Piperidin-1-yl-acetic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

The solution of ethyl 2-(piperidin-1-yl)acetate (1 g, 5.84 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 95% yield (0.8 g). LC-MS (ESI): Calculated mass: 143.1; Observed mass 144.4 [M+H]+ (rt: 0.21 min).

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 95% yield (0.8 g)
  6. customObserved mass 144.4 [M+H]+ (rt: 0.21 min)

Quellen und Nachweise

ORD-Eintrag
ord-a5f017eae4004649a15c9a90dbd1cc92
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447091B2

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